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臨床用途 |
屬化學療法劑。上呼吸道及下呼吸道感染症、腎臟及尿路感染症、男女兩性生殖器官感染症、腸胃道感染症、皮膚感染症、敗血病以及其他對本劑具有感受性菌所引起之感染症。
Contraindication: Infants < 2 mos. But PJP prophylaxis can begin at 1 month of age.
PO. Dosage expressed in terms of the trimethoprim (T) content.
Adults, 160 mg q12h.
Infants ≧ 2 m/o and children, 6-12 mg/kg/day in 2 doses.
Pneumocystis jiroveci (previous Pneumocystis carinii) pneumonia:
Adults, children ≧ 2 m/o, 15-20 mg/kg/day in 3-4 doses for 14-21 days.
Prevention of P. jiroveci pneumonia or Toxoplasmosis in HIV patients:
Adults & adolescents, 80-160 mg qd or on 3 consecutive days/wk.
Children ≧ 2 m/o, 150 mg/m2/day or 5-10 mg/kg/day for 3-7 days/wk; in q12h doses x 3 consecutive or alternating days; max. T 320 mg/day.
Acute Otitis Media: Children ≧ 2 m/o, 8 mg/kg/day in q12h.
GI Infections, Respiratory Tract Infections, Urinary Tract Infections (UTI): Adults, 160 mg q12h; children ≧ 2 m/o, 8-10 mg/kg/day in q12h.
UTI prophylaxis:
Adults, 40-80 mg qd or 3 times weekly.
Children ≧ 2 m/o, 2 mg/kg qd or 5 mg/kg twice weekly. |
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